PUBLICATIONS

Schönbichler A, Orlova A, Kreindl C, Endler L, Wilson R, Kosack L, Hofmann A, Viczenczova C, Darby J, Erdogan F., Patchett AL, Koren A, Kubicek S, Müller M, Flies AS, Bergthaler A, Moriggl R. Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers. EMBO J. 2025 Nov 3. doi: 10.1038/s44318-025-00603-0. PMID: 41184587.

Olaoye, Olasunkanmi ; Erdogan, F.; Gracia-Hernandez, Maria; Garcha, Harsimran; Sedighi, Abootaleb; Qirat, Ashraf; Nawar, Nabanita; Geletu, Mulu; … Improved Pharmacokinetic Profiles of HDAC6 Inhibitors Via Cap Group Modification. J. Med. Chem. 2025, Manuscript ID jm-2025-00479b.R2.

Erdogan, F.; Chowdhury, R.; Beldar, S.; Chandy, T. B.; Allan, R. G.; Araujo, E. D. D.; Gunning, P. T. Chemical Proteomics-Based Target Prioritization through a Residue Agnostic Ligandability Assessment Platform; preprint; Chemistry, Nat. Commun. 2024, Manuscript ID NCOMMS-24-35932.

Garcha., H.K., Nawar, N., Sorger, H., Erdogan, F., ... High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma. Pharmaceuticals (Basel). 2022 Oct 26;15(11):1321. doi: 10.3390/ph15111321. PMID: 36355493; PMCID: PMC9692247.

Erdogan F, Radu TB, Orlova A, Qadree AK, de Araujo ED, Israelian J, Valent P, Mustjoki SM, Herling M, Moriggl R, Gunning PT. JAK-STAT core cancer pathway: An integrative cancer interactome analysis. J Cell Mol Med. 2022 Apr;26(7):2049-2062. doi: 10.1111/jcmm.17228. Epub 2022 Mar 1.

Olaoye, O., Watson, P., Nawar, N., Geletu, M., Sedighi, A., Bukhari, S., Raouf, Y., Manaswiyoungkul, P., Erdogan, F., ... Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype, Journal of Medicinal Chemistry, 2021, 0022-2623,1520-4804, 64, 5, 2691-2704

Erdogan F, Qadree AK, Radu TB, Orlova A, de Araujo ED, Israelian J, Valent P, Mustjoki SM, Herling M, Moriggl R, Gunning PT. Structural and mutational analysis of member-specific STAT functions. Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130058. doi: 10.1016/j.bbagen.2021.130058. Epub 2021 Nov 11.

Olaoye OO, Watson PR, Nawar N, Geletu M, Sedighi A, Bukhari S, Raouf YS, Manaswiyoungkul P, Erdogan F, Abdeldayem A, Cabral AD, Hassan MM, Toutah K, Shouksmith AE, Gawel JM, Israelian J, Radu TB, Kachhiyapatel N, de Araujo ED, Christianson DW, Gunning PT. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. J Med Chem. 2021 Mar 11;64(5):2691-2704. doi: 10.1021/acs.jmedchem.0c01922. Epub 2021 Feb 12.

Hassan MM, Israelian J, Nawar N, Ganda G, Manaswiyoungkul P, Raouf YS, Armstrong D, Sedighi A, Olaoye OO, Erdogan F, Cabral AD, Angeles F, Altintas R, de Araujo ED, Gunning PT. Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting. J Med Chem. 2020 Aug 13;63(15):8634-8648. doi: 10.1021/acs.jmedchem.0c01025. Epub 2020 Jul 31.

Meneksedag-Erol, D., de Araujo, E. D. Erdogan, F., Seo, H., Dhe-Paganon, S., Gunning, P. T., Rauscher, S. (2020) Cancer Activating Mutations in STAT5B: Elucidating the Impact on Protein Structure and Dynamics using Atomistic Molecular Simulations. Biophys. J. doi:10.1016/j.bpj.2019.11.2779

Manaswiyoungkul P, Erdogan F, Olaoye OO, Cabral AD, de Araujo ED, Gunning PT. Optimization of a high-throughput fluorescence polarization assay for STAT5B DNA binding domain-targeting inhibitors. J Pharm Biomed Anal. 2020 May 30;184:113182. doi: 10.1016/j.jpba.2020.113182. Epub 2020 Feb 19.

Meneksedag-Erol, D., Araujo, E. D. D., Erdogan, F., Seo, H.-S., Dhe-Paganon, S., Gunning, P. T., & Rauscher, S. (2019). Uncovering the Molecular Basis for the Clinical N642H Mutation in STAT5B Using Atomistic Molecular Simulations. Biophysical Journal, 116(3). doi: 10.1016/j.bpj.2018.11.115

de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT. Structural and functional consequences of the STAT5BN642H driver mutation. Nat Commun. 2019 Jun 7;10(1):2517. doi: 10.1038/s41467-019-10422-7.

de Araujo ED, Manaswiyoungkul P, Erdogan F, Qadree AK, Sina D, Tin G, Toutah K, Yuen K, Gunning PT. A functional in vitro assay for screening inhibitors of STAT5B phosphorylation. J Pharm Biomed Anal. 2019 Jan 5;162:60-65. doi: 10.1016/j.jpba.2018.08.036. Epub 2018 Aug 18.

Erdogan, F. (2018) The Balance Between Natural Design and Rational Design in Drug Discovery. Health Science Inquiry. https://www.healthscienceinquiry.com/blogdrugdisc

Erdogan F, Lento C, Yaseen A, Nowroozi-Dayeni R, Kheyson S, Audette GF. Conjugative Mating Assays for Sequence-specific Analysis of Transfer Proteins Involved in Bacterial Conjugation. J Vis Exp. 2017 Jan 4;(119):54854. doi: 10.3791/54854.